AY-4
AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (Kd = 3.17 nM) . AY-4 effectively upregulates the levels of ferrous (Fe2+) and ferric (Fe3+) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871) ; Blue: E3 ligand Pomalidomide (HY-10984) ; Black: Linker, Pomalidomide-PEG3-acid (HY-174872) ) [1].
Product Specifications
UNSPSC
12352211
Target
Ferroptosis; PROTACs
Related Pathways
Apoptosis; PROTAC
Field of Research
Cancer
Smiles
NCCCNCCCCCCCCNC([C@@H](NC(COCCOCCOCCNC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O
Molecular Formula
C41H59N7O10
Molecular Weight
809.95
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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