DASK1
DASK1 is a selective and cereblon (CRBN) -based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1) . dASK1 forms a stable ternary complex with ASK1, facilitating ASK1 rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 demonstrates potent ASK1 degradation. dASK1 can be used for the research of steatohepatitis[1]. (Structure Note: Pink: ASK1 ligand (HY-174860) ; Blue: CRBN ligand (HY-10984) ; Black: linker; E3-linker (HY-174863) )
Product Specifications
CAS Number
[3064086-31-0]
UNSPSC
12352005
Target
ASK1; PROTACs
Related Pathways
Apoptosis; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(NCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)CCC(NC4=C(F)C=C(F)C(C(NC5=NC(C6=NN=CN6C(C)C)=CC=C5)=O)=C4)=O
Molecular Formula
C38H38F2N10O8
Molecular Weight
800.77
References & Citations
[1]Sarkar HS, et al. Rational design and discovery of potent PROTAC degraders of ASK1: a targeted therapy in MASH. RSC Med Chem. 2025 Jun 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Cereblon
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