ARN21929

ARN21929 is a Topoisomerase II inhibitor with an IC50 of 4.5 μM. ARN21929 exhibits excellent kinetic and thermodynamic solubility as well as metabolic stability. However, ARN21929 shows poor antiproliferative activity against A549, DU145, MCF7, HeLa, and A375 cells. ARN21929 can be used in the study of cancer[1].

Product Specifications

CAS Number

[2230854-98-3]

UNSPSC

12352005

Target

Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Concentration

10mM

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic; heat to 60°C)

Smiles

FC1=C(C=CC=C1)NC2=NC(C3=CC=NC=C3)=NC4=C2CNCC4

Molecular Formula

C18H16FN5

Molecular Weight

321.35

References & Citations

[1]Brindani N, et al. Tetrahydropyrido[4,3-d]pyrimidines as a new active scaffold for human topoisomerase II inhibitors. Sci Rep. 2025 Jun 4;15 (1) :19618.