WEE1-IN-12
WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. WEE1-IN-12 can inhibit the proliferation of HT29 cells (IC50: 1.07 μM), and when used in combination with Gemcitabine (HY-17026), the effect is better (IC50: 0.34 μM) . WEE1-IN-12 can be used in the research of tumors such as colon cancer[1].
Product Specifications
CAS Number
[3069940-37-7]
UNSPSC
12352005
Target
Wee1
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCCCN4CCC(CC4)N5C=C(C=N5)NC6=NC=C(C(OC7CC7)=N6)C(NC8=C(C=CC=C8Cl)Cl)=O)=C3C2=O)=O
Molecular Formula
C38H38Cl2N10O6
Molecular Weight
801.68
References & Citations
[1]Liang S H. Novel (1 H-Pyrazol-4-ylamino) pyrimidine Derivatives as Wee1 Inhibitors for Treatment of Cancer. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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