WEE1-IN-12

WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. WEE1-IN-12 can inhibit the proliferation of HT29 cells (IC50: 1.07 μM), and when used in combination with Gemcitabine (HY-17026), the effect is better (IC50: 0.34 μM) . WEE1-IN-12 can be used in the research of tumors such as colon cancer[1].

Product Specifications

CAS Number

[3069940-37-7]

UNSPSC

12352005

Target

Wee1

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCCCN4CCC(CC4)N5C=C(C=N5)NC6=NC=C(C(OC7CC7)=N6)C(NC8=C(C=CC=C8Cl)Cl)=O)=C3C2=O)=O

Molecular Formula

C38H38Cl2N10O6

Molecular Weight

801.68

References & Citations

[1]Liang S H. Novel (1 H-Pyrazol-4-ylamino) pyrimidine Derivatives as Wee1 Inhibitors for Treatment of Cancer. ACS Medicinal Chemistry Letters, 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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