C199

C199 is a PROTAC degrader targeting PRMT4 (DC50 = 106 nM) . C199 shows high selectivity for PRMT4 over other protein arginile methyltransferases. C199 exhibits strong cell degradation ability. C199 induces apoptosis in MM cell lines. C199 efficiently clears PRMT4 protein via the VHL-proteasome pathway. C199 has a relatively long half-life and shows strong anti-multiple myeloma (MM) tumor activity (Pink: Target protein ligand (HY-111109) ; Blue: E3 ligase ligand (HY-112078), E3 ligase ligand + linker (HY-174474) ; black: Linker) [1].

Product Specifications

UNSPSC

12352100

Target

Apoptosis; Histone Methyltransferase; PROTACs

Related Pathways

Apoptosis; Epigenetics; PROTAC

Field of Research

Cancer

Smiles

O=C(N[C@H](C1=CC=C(C=C1)C2=C(N=CS2)C)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCCCCCCCCCCCC(N4CCC5(CN(C5)C6=NC(C7=CC(OC[C@@H](CNC)O)=CC=C7Cl)=NC(C8=C(ON=C8C)C)=C6C)CC4)=O)=O)=O

Molecular Formula

C67H95ClN10O8S

Molecular Weight

1236.05

References & Citations

[1]Yong Ju, et al. Development of a Selective and Potent PRMT4 PROTAC Degrader with Efficacy against Multiple Myeloma in Vitro and in Vivo. J Med Chem. 2025 Jul 10. 68 (13) : 13973-13989.