RN277

RN277 is an inhibitor for LRRK2 type II kinase. RN277 can be used as a cellular tool targeting the LRRK2 inactive state. RN277 can inhibit LRRK1 kinase activity in vitro. RN277 inhibits LRRK2 kinase activity in vitro (IC50 = 70 nM) . RN277 reduces phosphorylation of Rab8a dose-dependently. RN277 can be studied in research for Parkingson’s disease[1].

Product Specifications

UNSPSC

12352005

Target

LRRK2

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

ClC1=NC(N2CCOCC2)=C(C(C3=CC=CC(NC(NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5)=O)=C3)=CN6)C6=N1

Molecular Formula

C31H33ClN8O2

Molecular Weight

585.10

References & Citations

[1]Raig ND, et al., (2025) Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2. bioRxiv [Preprint]. 2025 Feb 13:2024.09.17.613365.