CD-10

CD-10 is an orally active and BBB-penatrable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor. CD-10 binds to Keap1 with a KD value of 193 nM. CD-10 exhibits potent anti-oxidative and anti-inflammatory effects through Keap1-Nrf2 pathway activation, evidenced by reduced levels of MDA, IL-4, IL-10 and increased expression of HO-1. CD-10 effectively alleviated anxiety and depressive behaviors and restored serum neurotransmitter levels by promoting Nrf2 nuclear translocation in the chronic unpredictable mild stress (CUMS) mouse model. CD-10 can be used for the study of depression[1].

Product Specifications

UNSPSC

12352100

Target

Heme Oxygenase (HO) ; Interleukin Related; Keap1-Nrf2

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

COC1=CC=C(C=C1)S(=O)(N(C2=CC=C(C3=CC=CC=C32)N(S(=O)(C4=CC=C(C=C4)NC(CCN5CCC6(CC5)CCOC6)=O)=O)CC(N)=O)CC(N)=O)=O

Molecular Formula

C38H44N6O9S2

Molecular Weight

792.92

References & Citations

[1]Chen Y, et, al. Design of spiro-heterocyclic substituted diaminonaphthalene Keap1-Nrf2 protein-protein interaction inhibitors as novel anti-depressant agents. Eur J Med Chem. 2025 Jun 8;296:117848.