ROR1-IN-3

ROR1-IN-3 (Compound 24d) is a potent and highly selective ROR1 kinase inhibitor (IC50 = 17.6 nM) . ROR1-IN-3 demonstrates robust antitumor activity and inhibitory effect against ROR1 both in vitro and in vivo. ROR1-IN-3 has robust antiproliferative efficacy in vitro and in vivo. ROR1-IN-3 induces apoptosis in cancer cell lines. ROR1-IN-3 inhibits ROR1 downstream AKT/mTOR and NF-κB signaling pathway. ROR1-IN-3 can be studied in antitumor research[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; mTOR; NF-κB; ROR

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC1=C(C=C(C(NC2=CC=C3C(N(C=C3C4=CC=C(OC)N=C4)C)=C2)=O)C=C1)NC5=NC=CC(C6=CC=C(C=C6)OC7CC7)=N5

Molecular Formula

C36H32N6O3

Molecular Weight

596.68

References & Citations

[1]Zheng, Q., et al., (2025) . Optimization of 1-Methyl-3- (pyridin-3-yl) -1H-indol Derivatives as ROR1 Inhibitors with Improved Activity and Selectivity. Journal of medicinal chemistry, 68 (11), 11188–11216.