BChE-IN-41

BChE-IN-41 is a highly selective Butyrylcholinesterase (BChE) inhibitor (IC50 =12 nM, Ki = 6.6 nM) . BChE-IN-41 has high brain penetration with a brain-to-plasma ratio of 9.0. BChE-IN-41 has pro-cognitive effects on mice with AD-like symptoms induced by Scopolamine (HY-N0296) and Aβ1-42[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE) ; Tau Protein

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CN(S(=O)(C1=CC=C(C=CC=C2)C2=C1)=O)C[C@@H](C3)CCN3CC4=CC=CC=C4

Molecular Formula

C23H26N2O2S

Molecular Weight

394.53

References & Citations

[1]Urban Košak, et al. Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease. J Med Chem. 2025 Jun 12. 68 (11) : 11693-11723.