PeS-9

PeS-9 is an Androgen Receptor (AR) degrader that induces androgen receptor degradation PeS-9 induces mitochondrial and ER stress by promoting cytotoxic ROS production, leading to the release of mitochondrial cytochrome C and AIF. PeS-9 subsequently activates caspases-9 and -3, causing DNA fragmentation and apoptotic cell death. PeS-9 has anticancer activity against prostate cancer and exerts in vivo antitumor and antimetastatic activity with minor side effects. PeS-9 can be used for the study of targeting monotherapy against GLUT-1-overexpressing tumors[1].

Product Specifications

UNSPSC

12352100

Target

Androgen Receptor; Apoptosis; Calcium Channel; Caspase; Cytochrome P450; GLUT; Mitochondrial Metabolism; p38 MAPK; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COC1=C(CSC[C@H]2O[C@H]([C@@H]([C@H]([C@@H]2OC(C)=O)OC(C)=O)OC(C)=O)OC(C)=O)C(C3=C(C=CC=C3O)C1=O)=O

Molecular Formula

C26H28O13S

Molecular Weight

580.56

References & Citations

[1]Busenbender T, et al. 6- ((1,4-naphthoquinone-2-yl) methyl) thio-glucose conjugates, a novel targeted approach for advanced prostate cancer. Mol Cancer Ther. 2025 Apr 29.