TREM2 agonist-3

TREM2 agonist-3 (Compound 4i) is a TREM2 agonist, with a KD value of 19.0 µM. TREM2 agonist-3 shows a KD value of 39.8 µM for TREM1. TREM2 agonist-3 induces an increase in phospho-SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases involving TREM2 dysfunction[1].

Product Specifications

UNSPSC

12352100

Target

Syk; TREM receptor

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.39

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(S1)C2=CC(C(NC)=O)=CC(NC(C3CC(C3)=C)=O)=C2OC)=O

Molecular Formula

C21H22N2O4S

Molecular Weight

398.48

References & Citations

[1]Nada H, et al. TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.