TREM2 agonist-3
TREM2 agonist-3 (Compound 4i) is a TREM2 agonist, with a KD value of 19.0 µM. TREM2 agonist-3 shows a KD value of 39.8 µM for TREM1. TREM2 agonist-3 induces an increase in phospho-SYK levels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases and other diseases involving TREM2 dysfunction[1].
Product Specifications
UNSPSC
12352100
Target
Syk; TREM receptor
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(S1)C2=CC(C(NC)=O)=CC(NC(C3CC(C3)=C)=O)=C2OC)=O
Molecular Formula
C21H22N2O4S
Molecular Weight
398.48
References & Citations
[1]Nada H, et al. TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TREM-1; TREM-2
Available Sizes
Curated Selection
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