ELQ-121

ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (QO) -site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research[1][2][3].

Product Specifications

CAS Number

[1228283-36-0]

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

FC1=C2C(NC(C)=C(CCCCCCC)C2=O)=CC(F)=C1

Molecular Formula

C17H21F2NO

Molecular Weight

293.35

References & Citations

[1]Probst, A. S., et al., (2025) . In vivo screen of Plasmodium targets for mosquito-based malaria control. Nature. Advance online publication. |[2]Eberhard, N., et al., (2020) . Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites. Frontiers in veterinary science, 7, 96.|[3]Winter, R., et al., (2011) . Optimization of endochin-like quinolones for antimalarial activity. Experimental parasitology, 127 (2), 545–551.