Osimertinib dimer

Osimertinib dimer is a dimer of Osimertinib (HY-15772) . Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1][2].

Product Specifications

CAS Number

[2564638-97-5]

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Field of Research

Cancer

Smiles

O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CC[N+](C)(CCC(NC5=CC(NC6=NC(C7=CN(C)C8=C7C=CC=C8)=CC=N6)=C(C=C5N(CCN(C)C)C)OC)=O)C)C)OC)C=C

Molecular Formula

C56H67N14O4+

Molecular Weight

1000.22

References & Citations

[1]Yuan BZ, et al. Oxitinib dimer, preparation method and application thereof. CN112028880A. |[2]Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4 (9) :1046-61.