WB156
WB156 is a dual MDM2 and GSPT1 degrader. WB156 can recruit CRBN (Cereblon, a substrate receptor of the E3 ubiquitin-ligase complex) to induce the ubiquitination-proteasome pathway-mediated degradation of MDM2 and GSPT1. WB156 is promising for research of cancers, such as leukemia[1].
Product Specifications
CAS Number
[2368944-44-7]
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(N1CCN(CC1)CC#CC2=C3C(C(N(C4C(NC(CC4)=O)=O)C3)=O)=CC=C2)N5[C@H](C6=CC=C(C=C6)Cl)[C@H](C7=CC=C(C=C7)Cl)N=C5C8=C(C=C(C=C8)C(C)(C)C)OCC
Molecular Formula
C48H48Cl2N6O5
Molecular Weight
859.84
References & Citations
[1]Tandon I, et al. Characterization of a dual degrader of MDM2 and GSPT1. Eur J Med Chem. 2025 May 21;295:117793.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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