RCD405

RCD405 is a bronchodilator. RCD405 exerts relaxant effects by acting directly on human airway smooth muscle (hASM) with an EC50 value of 12 μM for histamine-induced contractions and 45.71 μM for carbachol-induced contractions. RCD405 inhibits cholinergic and histaminergic tone and reduces electrically stimulated (EFS) -induced contractions. RCD405 is promising for research of asthma and chronic obstructive pulmonary disease (COPD) [1].

Product Specifications

CAS Number

[2408134-22-3]

UNSPSC

12352101

Target

Others

Related Pathways

Others

Field of Research

Inflammation/Immunology

Smiles

OC1=C(O)C(Cl)=C(CCN(C(CSC2=CN=C(C(F)(F)F)C=C2)=O)C3)C3=C1Cl

Molecular Formula

C17H13Cl2F3N2O3S

Molecular Weight

453.26

References & Citations

[1]Rogliani P, et al. Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways. Br J Pharmacol. 2025 May 19.