CPS-021
CPS-021 is a selective PAK4 PROTAC degrader with a DC50 of 50 nM. CPS-021 has potent antimigratory and invasive activity and significantly suppresses the invasion and metastasis of tumor cells in A549-luc lung metastasis mice model[1]. Pink: PAK4 ligand (HY-174822) ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker
Product Specifications
UNSPSC
12352005
Target
Cadherin; PAK; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; PROTAC
Field of Research
Cancer
Smiles
O=C(N1CCN(CC1)CCCCCCCC(N2CCN(CC2)CCNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)C(C6=CC=C(C#CC7(O)CCCCC7)C=C86)=CN8C9=NC(N)=NC=C9
Molecular Formula
C52H63N11O7
Molecular Weight
954.13
References & Citations
[1]Wang H, et al. Design, Synthesis, and Biological Evaluation of Selective PAK4 Degrader for the Treatment of Lung Tumor Metastasis. J Med Chem. 2025 Jun 12;68 (11) :11231-11269.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK4
Curated Selection
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