PROTAC SARS-CoV-2 Mpro degrader-4

PROTAC SARS-CoV-2 Mpro degrader-4 (Compound LLP019) is a SARS-CoV-2 MPro PROTAC degrader with a DC50 value of 4.7 μM. PROTAC SARS-CoV-2 Mpro degrader-4 induces MPro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Mpro degrader-4 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717) ; Black: linker (HY-42149) ; Blue: Thalidomide-4-O-CH2-COO (t-Bu) (HY-42771) [1].

Product Specifications

UNSPSC

12352005

Target

PROTACs; SARS-CoV; Virus Protease

Related Pathways

Anti-infection; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

CCOC1=C(NC(CCOCCOCCNC(COC2=C(C(N(C3CCC(NC3=O)=O)C4=O)=O)C4=CC=C2)=O)=O)C=C(C(NC5=CC(Cl)=C(F)C=C5)=C(C#N)C=N6)C6=C1

Molecular Formula

C40H37ClFN7O10

Molecular Weight

830.21

References & Citations

[1]Veeck C, et al. Discovery of an Antiviral PROTAC Targeting the SARS-CoV-2 Main Protease Using an Allosteric Warhead[J]. bioRxiv, 2025: 2025.05. 03.652023.