EN1441
EN1441 is a covalent degrader targeting the androgen receptor (AR) with an EC50 value of 4.2 μM and its truncated variant AR-V7. EN1441 selectively and potently degrades both AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 is promising for research of androgen-independent prostate cancers[1].
Product Specifications
CAS Number
[2196448-47-0]
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.67
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=CC2=C(NC(C(N2C(C=C)=O)(C)C)=O)C=C1
Molecular Formula
C13H13ClN2O2
Molecular Weight
264.71
References & Citations
[1]Zammit CM, et al. Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. bioRxiv [Preprint]. 2025 Feb 16:2025.02.12.637117.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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