NUV-244
NUV-244 is a PNPLA3 I148M degrader. NUV-244 reduces PNPLA3 I148M levels on lipid droplets via BFAR-mediated ubiquitin-proteasome degradation[1].
Product Specifications
UNSPSC
12352005
Target
PNPLA3
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC1=CC(CC2=NC(C)=C(C(NC3=CC(O)=CC=C3Cl)=O)S2)=CC=C1
Molecular Formula
C19H17ClN2O2S
Molecular Weight
372.87
References & Citations
[1]Steigemann P, et al. Identification of NUV-244 as a PNPLA3 I148M degrading small molecule. iScience. 2025 Apr 8;28 (5) :112384.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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