JNJ-9676
JNJ-9676 is an orally active inhibitor of membrane (M) protein. JNJ-9676 has in vitro antiviral activity against SARS-CoV-2, SARS-CoV, and sarbecovirus from bats and pangolins. JNJ-9676 inhibits viral assembly by stabilizing the conformational changes of the M protein dimer, preventing the release of infectious viruses. JNJ-9676 has significant antiviral effects and can be used in research on the prevention and treatment of coronavirus infections[1].
Product Specifications
CAS Number
[3026520-19-1]
UNSPSC
12352005
Target
DNA/RNA Synthesis; SARS-CoV
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
99.74
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
N#CC1=CC=CC(NC(C2=C3N(N=C2)C[C@@H](N(C4=CC=C(C=C4)C(F)(C5=CC=CC=C5)F)C3=O)C)=O)=C1
Molecular Formula
C28H21F2N5O2
Molecular Weight
497.50
References & Citations
[1]Van Damme E, et al. A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein. Nature. 2025 Apr;640 (8058) :506-513.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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