IDO1/TDO-IN-8

IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor that can penetrate the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. IDO1/TDO-IN-8 reduces the kynurenine/tryptophan ratio by regulating the kynurenine pathway of tryptophan metabolism. IDO1/TDO-IN-8 has a neuroprotective effect and can alleviate motor dysfunction and improve depressive behavior. IDO1/TDO-IN-8 can be used in the study of Parkinson's disease combined with depression[1].

Product Specifications

CAS Number

[3085413-22-2]

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO)

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC1=CC(C2=NC=CC3=C2NC4=C3C=CC=C4)=C(C)S1

Molecular Formula

C17H14N2S

Molecular Weight

278.37

References & Citations

[1]Chen X, et al. Proof of concept study for developing 1-thienyl-β-carboline derivatives as IDO1 and TDO dual inhibitors to treat Parkinson's disease complicating depression. Eur J Med Chem. 2025 Jul 5;291:117597.