JR5-26B
JR5-26B is an orally active apoptosis inducer. JR5-26B induces cell death through copper-mediated apoptosis and necroptosis. JR5-26B exhibits antiproliferative activity on MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells with IC50s of 0.6, 4.4, 8.0, 1.1, and 3.4μM, respectively[1].
Product Specifications
CAS Number
[2446965-04-2]
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(NC1=C2N=CC=CC2=CC(F)=C1)C3=NC=C(N=C3)N4C[C@@]5([C@H]([C@@]5(C4)[H])N)[H]
Molecular Formula
C19H17FN6O
Molecular Weight
364.38
References & Citations
[1]Roy J, et al. Copper-KRAS-COX2 Axis: A Therapeutic Vulnerability in Pancreatic Cancer. J Med Chem. 2025 Apr 24;68 (8) :8400-8428.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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