Sirtuin modulator 8
Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21) . Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases[1].
Product Specifications
CAS Number
[925437-38-3]
UNSPSC
12352005
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Metabolic Disease; Inflammation/Immunology
Purity
96.24
Smiles
O=C(C1=NC2=CC=CC=C2N=C1)NC3=C(C4=CN5C(CN6CCC(CC6)N)=CSC5=N4)C=CC=C3
Molecular Formula
C26H25N7OS
Molecular Weight
483.59
References & Citations
[1]Olivier Boss, et al. Biomarkers of sirtuin activity and methods of use thereof.WO2008115518A2.US.2008-09-25
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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