NP1867

NP1867 is a potent, selective, covalent PMS2 inhibitor. NP1867 functionally inhibits DNA mismatch repair. NP1867 enhances immune surveillance. NP1867 can be used in the research of colorectal cancer[1][2].

Product Specifications

CAS Number

[2930070-08-7]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer; Inflammation/Immunology

Smiles

CN(C)C/C=C/C(NC1=C2C(CN(C2)C(C3=C(C(C)=C(C=C3O)O)OCC4CCCCC4)=O)=CC=C1)=O

Molecular Formula

C29H37N3O5

Molecular Weight

507.62

References & Citations

[1]Blagg J, et al. Abstract C086: NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples. Molecular Cancer Therapeutics, 2023, 22 (12_Supplement) : C086-C086. |[2]Piumatti E, et al. Pharmacological inhibition of PMS2 increases tumor mutational burden, induces microsatellite instability and elicits immune mediated rejection in vivo[J]. Cancer Research, 2024, 84 (6_Supplement) : 6011-6011.