RSK-IN-2
RSK-IN-2 (Compound 3e) is a RSK inhibitor, with IC50 s of 37.89 nM (RSK2), 30.78 nM (RSK1), 20.51 nM (RSK3), 91.28 nM (RSK4) . RSK-IN-2 inhibits tumor cell proliferation, induces apoptosis and causes cell cycle arrest in the G2/M phase[1].
Product Specifications
CAS Number
[3011713-80-4]
UNSPSC
12352005
Target
Apoptosis; Ribosomal S6 Kinase (RSK)
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Cancer
Purity
99.32
Solubility
DMSO : 35 mg/mL (ultrasonic)
Smiles
CN1CCN(C2=CC(OC)=C(NC3=NC(NC4=CC=CC=C4C(NCCO)=O)=C(Cl)C=N3)C=C2)CC1
Molecular Formula
C25H30ClN7O3
Molecular Weight
512.00
References & Citations
[1]Han C, et al. Discovery of 2,4-dianilinopyrimidine derivatives as novel p90 ribosomal S6 protein kinase (RSK) inhibitors. Eur J Med Chem. 2025 Jul 5;291:117590.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RSK2; RSK3; RSK4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7030220-01 0.02 mg
Recombinant Surface presentation of antigens protein SpaQ (spaQ)
Ask
View Details 
MBS7030220-02 0.1 mg
Recombinant Surface presentation of antigens protein SpaQ (spaQ)
Ask
View Details MBS7030220-03 5x 0.1 mg
Recombinant Surface presentation of antigens protein SpaQ (spaQ)
Ask
View Details 