Anticancer agent 271
Anticancer agent 271 (compound 5C) has antiproliferative activity against lung (A549), colon (Caco-2) cancer cell lines, and human lung fibroblast (WI38) with an IC50 value of 9.18 μM on A549 cells. Anticancer agent 271 downregulates PI3K and mTOR gene expression that can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
EGFR; mTOR; PI3K
Related Pathways
JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C(C=C1)=CC=C1N(N=N2)C=C2COC(C=CC=C3)=C3C4=NC(C5=CC=C(C(F)(F)F)C=C5)=NO4)=O
Molecular Formula
C26H18F3N5O3
Molecular Weight
505.45
References & Citations
[1]Mohammed Salah Ayoup, et al. Investigating the Anticancer Activity of Novel 1,2,4-Oxadiazole-Linked 1,2,3-Triazole Moieties via EGFR/pI3K/mTOR Cascade Down-Regulation. Polycyclic Aromatic Compounds. 26 Feb 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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