G-6599

G-6599 is a SMARCA2/A4 target-anchored monovalent degrader with DC50 values of 0.018 nM and 0.056 nM, respectively. G-6599 has degradation activity and anti-proliferative effects in AR-dependent prostate cancer cell lines[1].

Product Specifications

CAS Number

[2901806-51-5]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Related Pathways

Epigenetics

Field of Research

Cancer

Purity

92.10

Smiles

OC1=CC=CC=C1C2=CC(N3CC4N(C5=CC(C#CCCN6CCCCCC6)=NC=C5)C(CC4)C3)=C(N)N=N2

Molecular Formula

C31H37N7O

Molecular Weight

523.67

References & Citations

[1]Elisia Villemure, et al. Rational design of potent small molecule SMARCA2/A4 (BRM/BRG1) degraders acting via the recruitment of FBXO22. bioRxiv. 2025, 3, 7.