CB039

CB039 is a selective a molecular glue degrader that targets RBM39 (RNA-binding protein 39) . CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer[1].

Product Specifications

CAS Number

[3056259-55-0]

UNSPSC

12352005

Target

Molecular Glues

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

CC1=C2C(NC=C2C#N)=C(C=C1)NS(C3=CC=CC(NC(C(N4[C@H](CCC4)CO)=O)=O)=C3)(=O)=O

Molecular Formula

C23H23N5O5S

Molecular Weight

481.52

References & Citations

[1]Lyu X, et al. Synthesis of an RBM39 Degrader That Downregulates CEP192 and Induces Disorganized Spindle Structures. J Med Chem. 2025 Apr 10;68 (7) :7807-7826.