UNC9426
UNC9426 is a potent and selective TYRO3 inhibitor (IC50 = 2.1 nM), demonstrating 276-fold and 90-fold selectivity over MERTK and AXL, respectively. UNC9426 reduces platelet aggregation without increasing bleeding time and blocks TYRO3-dependent functions in tumor cells and macrophages. UNC9426 demonstrates a favorable safety profile with no significant increase in bleeding risk in vivo. UNC9426 can be used for functional studies of TYRO3-dependent phenotypes such as non-small cell lung cancer (NSCLC) [1].
Product Specifications
CAS Number
[3051784-94-9]
UNSPSC
12352005
Target
TAM Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Purity
99.51
Solubility
DMSO : 20.59 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H](CC1)CC[C@@H]1N2C=C(C3=CC=C(C=C3)CN4CCN(CC4)C)C5=CN=C(N=C52)NC6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6
Molecular Formula
C32H34F6N6O
Molecular Weight
632.64
References & Citations
[1]Kong D, et al. UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor. J Med Chem. 2025 Mar 27;68 (6) :6665-6682
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Mer; Tyro3
Available Sizes
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