10-SLF
10-SLF is a PROTAC FKBP12 degrader. 10-SLF induces a ternary complex between FKBP12 and FBXW7-R465C, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF selectively reduces FKBP12 levels in cells expressing FBXW7-R465C. Pink: FKBP12 ligand (HY-170988) ; Black: linker (HY-W004640) ; Blue: E3 ligase ligand[1].
Product Specifications
CAS Number
[2765058-89-5]
UNSPSC
12352005
Target
FKBP; PROTACs
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@H](CCC2=CC(OC)=C(C=C2)OC)C3=CC=CC(OCC(NCCCOCCOCCOCCCN(C(CCl)=O)C(C4=CC=C(C=C4)Cl)C(NCC5=CC=CC=C5)=O)=O)=C3
Molecular Formula
C59H76Cl2N4O13
Molecular Weight
1120.16
References & Citations
[1]Basu AA, et al. Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation. bioRxiv [Preprint]. 2024 Dec 4:2024.12.03.626601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
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