TWH106

TWH106 is an inhibitor for Cyclophilin (Cyp) that exhibits good affinity to CypA and CypB with KD of 53 nM and 139 nM. TWH106 inhibits the replication of HIV and HCV, exhibiting antiviral activity[1].

Product Specifications

UNSPSC

12352005

Target

Cyclophilin; HCV; HIV

Related Pathways

Anti-infection; Immunology/Inflammation

Field of Research

Infection

Smiles

O=C([C@@H]1CCCN(N1)C([C@@H](NC([C@@H](NC(C/C=C/2)=O)CC3=CC=C(C=C3)[N+]([O-])=O)=O)C)=O)O[C@H](C)C4=CC=C5C=CC2=CC5=N4

Molecular Formula

C32H34N6O7

Molecular Weight

614.65

References & Citations

[1]Newton LS, et al., Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cyclophilin A; Cyclophilin B

Curated Selection

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