MS9024
MS9024 is the degrader for DNA methyltransferase 1 that degrades DNMT1 in cell HCT116 through the ubiquitin-proteasome pathway with a DC50 of 35 nM (DC50 in MDA-MB-468 and H1299 is 254 nM and 101 nM) . MS9024 also inhibits DNMT1 with an IC50 of 0.43 μM[1].
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.83
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
CCC1=C(C(SC(C2=CC=CC=C2)C(N)=O)=NC(N(CC(NC)=O)C)=C1C#N)C#N
Molecular Formula
C21H22N6O2S
Molecular Weight
422.50
References & Citations
[1]Qian C, et al., Structure-Activity Relationship Studies of DNA Methyltransferase 1 Monovalent Degraders. J Med Chem. 2025 Feb 13;68 (3) :2903-2919.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
TRAF4 (TNF Receptor Associated Factor 4, TNF Receptor-associated Factor 4, TRAF 4, TRAF-4, Cysteine-rich Domain Associated with RING and Traf Domains Protein 1, CART1, Metastatic Lymph Node Gene 62 Protein, MLN 62, MLN62, RING Finger Protein 83, RNF83) (M
TRAF4 (TNF Receptor Associated Factor 4, TNF Receptor-associated Factor 4, TRAF 4, TRAF-4, Cysteine-rich Domain Associated with RING and Traf Domains Protein 1, CART1, Metastatic Lymph Node Gene 62 Protein, MLN 62, MLN62, RING Finger Protein 83, RNF83) (M
