NNRT-IN-8
NNRT-IN-8 (compound 9K) is a potent non-nucleoside reverse transcriptase inhibitor with EC50 values of 0.0014, 0.0041, 0.0077 µM for WT HIV-1, K103N, E138K, respectively[1].
Product Specifications
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC1=CC(/C=C/C#N)=CC(C)=C1OC2=CC=NC(NC3=CC=C(C=C3)CN4CCN(CC4)C=O)=N2
Molecular Formula
C27H28N6O2
Molecular Weight
468.55
References & Citations
[1]Ji X, et al. Discovery of novel diarypyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant region I within NNRTI binding pocket. Eur J Med Chem. 2025 Oct 5;295:117787.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Curated Selection
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