RIPK3-IN-5

RIPK3-IN-5 (compound 32) is a potent RIPK3 inhibitor with an IC50 of 27 nM. RIPK3-IN-5 also inhibits necroptosis with an EC50 of 0.45 μM[1].

Product Specifications

UNSPSC

12352101

Target

Necroptosis; RIP kinase

Related Pathways

Apoptosis

Field of Research

Inflammation/Immunology

Smiles

CN1CCN(C2=CC=C(C3=CC4=NC=NC(NC5=C(F)C=CC=C5F)=C4C=C3)C=N2)CC1

Molecular Formula

C24H22F2N6

Molecular Weight

432.47

References & Citations

[1]Parry C W, et al. Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras[J]. Journal of Medicinal Chemistry, 2025, 68 (9) : 9129-9161.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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