MDAR-IN-1
MDAR IN-1 (Compound 5m) is a brain-penetrant inhibitor of acetylcholinesterase (AChE) and antagonist of the GluN1/GluN2B subtype of NMDAR receptor. MDAR IN-1 effectively inhibits AChE activity, enhances cholinergic neurotransmission, and blocks NMDAR, reducing excitatory neurotoxicity. MDAR IN-1 is promising for research of Alzheimer's disease[1].
Product Specifications
UNSPSC
12352100
Target
Cholinesterase (ChE) ; iGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=CSC(C2=CC=C3N=C4CCCCC4=C(C3=C2)N)=C1
Molecular Formula
C18H18N2S
Molecular Weight
294.41
References & Citations
[1]Svobodova B, et al. Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment. Eur J Med Chem. 2025 Aug 5;292:117678.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; NMDA Receptor
Curated Selection
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