PUC-10
PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. In silico predictions suggest that PUC-10 is orally active and can cross the blood-brain barrier. PUC-10 can induce autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 can be used in the research of neurological disorders[1].
Product Specifications
CAS Number
[2064126-76-5]
UNSPSC
12352005
Target
5-HT Receptor; Autophagy; mTOR
Related Pathways
Autophagy; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
OC(C1=CN(S(=O)(C2=C3C=CC=CC3=CC=C2)=O)C4=C1C=CC=C4)CN5CCN(C6=CC=CC=C6OC)CC5
Molecular Formula
C31H31N3O4S
Molecular Weight
541.66
References & Citations
[1]Alcaíno JM, et al. Novel 5-HT6R modulators as mTOR-dependent neuronal autophagy inductors. Sci Rep. 2025 Mar 11;15 (1) :8380.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor
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