Darlifarnib
Darlifarnib (Compound (S) -058) is the inhibitor for farnesyl transferase and geranylgeranyltransferase with IC50 ≤ 10 nM and > 1000 nM. Darlifarnib exhibits good metabolic stability in human and mouse liver microsomes with the half-life time > 100 min[1].
Product Specifications
CAS Number
[3065226-39-0]
Product Name Alternative
KO-2806
UNSPSC
12352005
Target
Farnesyl Transferase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#CC1=CC(C2=CC(OCC3=CC([C@@]4(C5=CN=CN5C)N)=CC=C3C#N)=CC=C2)=C6C=C4C=CC6=N1
Molecular Formula
C29H20N6O
Molecular Weight
468.51
References & Citations
[1]Zhu X, et al., Macrocyclic compounds having farnesyltransferase inhibitory activity. WO2023102378
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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