Toyaburgine
Toyaburgine is a unique isoquinoline compound that exhibits anti-tumor activity. It packs a punch by disrupting the PI3K/AKT/mTOR signaling pathway, causing significant morphological changes and cell death in MIA PaCa-2 cells. On top of that, it puts the brakes on cell migration and colony formation. This compound is showing a lot of promise in the realm of pancreatic cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Akt; mTOR; PI3K
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
BrC(C=C1)=CC=C1C(C=C2)=CC=C2[N+]([C@@H](C)C3)=C(C)C4=C3C=C(OC)C=C4OC.O=C([O-])C(F)(F)F
Molecular Formula
C27H25BrF3NO4
Molecular Weight
564.39
References & Citations
[1]Awale S, et al. Toyaburgine, a Synthetic N-Biphenyl-Dihydroisoquinoline Inspired by Related N, C-Coupled Naphthylisoquinoline Alkaloids, with High In Vivo Efficacy in Preclinical Pancreatic Cancer Models. ACS Chem Biol. 2025 Mar 6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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