ROCK/HDAC-IN-2

ROCK/HDAC-IN-2 (Compound C-9) is a ROCK/HDAC inhibitor, with IC50 values of 0.185 µM, 0.8 µM, and 0.7 µM for HDAC6, ROCK1, and ROCK2, respectively. ROCK/HDAC-IN-2 can induce apoptosis and changes in mitochondrial membrane potential in cancer cells, demonstrating significant antitumor activity. ROCK/HDAC-IN-2 can be used in the research of pancreatic ductal adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC) [1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; HDAC; ROCK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

O=C(NO)CCCCCCCN1CCCN(CC1)S(=O)(C2=CC=CC3=C2C=CN=C3)=O

Molecular Formula

C22H32N4O4S

Molecular Weight

448.58

References & Citations

[1]Beljkas M, et al. Pioneering first-in-class HDAC-ROCK inhibitors as potential multitarget anticancer agents. Future Med Chem. 2025 Feb;17 (4) :393-407.