HYS-072

HYS-072 is an orally active derivative of chrysin (HY-14589) with antitumor activity. HYS-072 induces apoptosis and autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway and suppresses tumor growth in vivo in xenograft models by modulating autophagy-related pathways. HYS-072 can be used in the research of triple-negative breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; Autophagy; mTOR; PI3K

Related Pathways

Apoptosis; Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC1=CC=C(NC(NCCCCOC2=CC(O)=C3C(OC(C4=CC=CC=C4)=CC3=O)=C2)=O)C=C1

Molecular Formula

C27H26N2O5

Molecular Weight

458.51

References & Citations

[1]Hou Y, et al. A novel chrysin derivative HYS-072 induces apoptosis and autophagy in Triple-negative breast cancer cells. Nat Prod Res. 2025 Feb 11:1-7.