E10i-494

E10i-494 is an ionizable cationic branched endosomal disruptor (BEND) lipid. E10i-494 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vitro. E10i-494 can enhance transfection efficiency[1].

Product Specifications

CAS Number

[3031773-77-7]

UNSPSC

12352211

Target

Liposome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Smiles

OC(CCCCCCCCCCC(C)C)CN(CCN1CCN(CC1)CCOCCN(CC(CCCCCCCCCCC(C)C)O)CC(CCCCCCCCCCC(C)C)O)CCOCCN(CC(CCCCCCCCCCC(C)C)O)CC(CCCCCCCCCCC(C)C)O

Molecular Formula

C89H183N5O7

Molecular Weight

1435.43

References & Citations

[1]Padilla, M. S., et al., (2025) . Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nature communications, 16 (1), 996.