BI-9740

BI-9740 is an orally active and selective cathepsin C (CatC) inhibitor, with an IC50 of 0.6 nM in mice and 2.6 nM in rats. BI-9740 can inhibit the production of active neutrophil elastase. Additionally, BI-9740 is capable of reducing the activities of neutrophil elastase and cathepsin G in the bone marrow of rats, alleviating pathological damage to grafts after heart transplantation, shortening the reperfusion time, and improving left ventricular function. BI-9740 can be used in research related to organ transplantation[1].

Product Specifications

CAS Number

[1628596-25-7]

UNSPSC

12352005

Target

Cathepsin; Elastase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

CN1C2=CC(C3=CC(F)=C(C=C3)C[C@@H](C#N)NC([C@@H]4[C@]5([H])C[C@](CC5)([H])N4)=O)=CC=C2CC1=O

Molecular Formula

C25H25FN4O2

Molecular Weight

432.49

References & Citations

[1]Liu B, et al. Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats. J Transl Med. 2023 Nov 9;21 (1) :799.