GLP-1R agonist 32
GLP-1R agonist 32 (Compound 111) is an orally active and highly potent GLP-1R agonist with an EC50 value of 0.017 nM. GLP-1R agonist 32 exerts glucose-regulating activity by activating GLP-1R to stimulate cAMP production, promoting insulin secretion, inhibiting glucagon release, and delaying gastric emptying. GLP-1R agonist 32 is promising for research of type 2 diabetes, obesity, and related metabolic disorders[1].
Product Specifications
CAS Number
[3047875-57-7]
UNSPSC
12352005
Target
GCGR
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
ClC(C=C1)=CC=C1[C@H]2OC3=CC=CC(C(CC4)CCN4CC(N(C5=CC(C(O)=O)=C6)C[C@@H]7CCO7)=NC5=C6F)=C3OC2
Molecular Formula
C32H31ClFN3O5
Molecular Weight
592.06
References & Citations
[1]Chunliang Lu, et al. Heterocyclic glp-1 agonists. WO2024131869A1. 2024-06-27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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