TD-6301
TD-6301 is a bladder-selective M2/4 muscarinic receptor antagonist. TD-6301 binds to and blocks M2/4 muscarinic receptors with high selectivity, especially human M2 receptors with strong affinity (Ki = 0.36 nM) . TD-6301 inhibits volume-induced bladder contractions (ID50 = 0.075 mg/kg) . TD-6301 can be used in the research of overactive bladder[1].
Product Specifications
CAS Number
[690999-15-6]
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology
Smiles
NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3CN(CC3)CCCCCCCN(C4CCN(CC4)CC5=CN=CC=C5OC)C(C)C)=O
Molecular Formula
C40H57N5O2
Molecular Weight
639.91
References & Citations
[1]McNamara A, et al. Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist. Eur J Pharmacol. 2009 Mar 1;605 (1-3) :145-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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