AZD1134

AZD1134 is an orally active, brain-penetrant and highly selective 5-HT1B receptor antagonist with IC50 values of 2.9 nM (human) and 0.108 nM (guinea pig), respectively. AZD1134 increases synaptic serotonin levels in guinea pigs. AZD1134 is promising for research of psychiatric disorders, such as depression and anxiety[1].

Product Specifications

CAS Number

[442548-99-4]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=CC(C2=C(O1)C(N3CCN(C)CC3)=CC(F)=C2)=O)NC4=CC=C(N5CCN(C(CC)=O)CC5)C=C4

Molecular Formula

C28H32FN5O4

Molecular Weight

521.58

References & Citations

[1]Maier DL, et al. [N-methyl-3H3]AZ10419369 binding to the 5-HT1B receptor: in vitro characterization and in vivo receptor occupancy. J Pharmacol Exp Ther. 2009 Jul;330 (1) :342-51.