QLS-81
QLS-81 is a Nav1.7 channel inhibitor (IC50: 1.5 μM) . QLS-81 has significant analgesic activity and can relieve neuropathic and inflammatory pain. QLS-81 exerts frequency-dependent inhibitory effects by inhibiting the inactivated state of Nav1.7 channels. QLS-81 can be used in the study of chronic pain[1].
Product Specifications
CAS Number
[2835455-57-5]
UNSPSC
12352005
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C[C@H](NCCCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O
Molecular Formula
C19H23FN2O2
Molecular Weight
330.40
References & Citations
[1]Niu HL, et al. Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain. Acta Pharmacol Sin. 2021 Aug;42 (8) :1235-1247.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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