SK2188
SK2188 is a highly efficient and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM) . SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252) ; Blue: Thalidomide (HY-14658) ; Black: Linker: Amino-PEG4-alcohol (HY-W008005) ) [1].
Product Specifications
CAS Number
[3038446-94-2]
Product Name Alternative
JB325
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase; Caspase; PROTACs
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=C3C1=O
Molecular Formula
C43H46ClFN6O10S
Molecular Weight
893.38
References & Citations
[1]Muhammad Rishf, et al. Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma. Eur J Med Chem. 2023 Feb 5:247:115033.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Caspase 3; Caspase 7; Cereblon
Available Sizes
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