F4-Trp
F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand targeting the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) . F4-Trp is promising for research of neurotransmission, addiction, and related diseases, such as neurological diseases[1].
Product Specifications
CAS Number
[72120-72-0]
Product Name Alternative
4,5,6,7-Tetrafluoro-L-tryptophan
UNSPSC
12352209
Target
NAChR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.99
Solubility
DMSO : 1.96 mg/mL (ultrasonic; warming; adjust pH to 5 with 1 M HCL; heat to 60°C)
Smiles
OC([C@@H](N)CC(C1=C(F)C(F)=C2F)=CNC1=C2F)=O
Molecular Formula
C11H8F4N2O2
Molecular Weight
276.19
References & Citations
[1]Knox HJ, et al. Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor. J Am Chem Soc. 2022 Sep 7;144 (35) :16101-16117.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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